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Mouse Anti-PRMT2 Recombinant Antibody (3A3) (CBMAB-P2934-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Arginine Methyltransferase 2. The antibody can be used for immunoassay techniques, such as IF, IHC-P, WB.
See all PRMT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A3
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human PRMT2(NP_001526) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Arginine Methyltransferase 2
Introduction
RMT2 (Protein Arginine Methyltransferase 2) is a protein coding gene. Among its related pathways are mRNA Splicing-Major Pathway and Retinoblastoma (RB) in Cancer. Gene Ontology annotations related to this gene include protein homodimerization activity and transcription coactivator activity.
Entrez Gene ID
3275
UniProt ID
P55345
Alternative Names
HRMT1L1
Function
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Biological Process
Developmental cell growthISS:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G1/S transition of mitotic cell cycleISS:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-arginine methylationIEA:InterPro
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein methylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
Isoform PRMT2Alpha
Nucleus
Excluded from nucleolus.
Isoform PRMT2Beta
Cytoplasm
Nucleus
Nucleus, nucleolus
Isoform PRMT2Gamma
Nucleus
Excluded from nucleolus.
Isoform PRMT2L2
Cytoplasm
Nucleus
Predominantly cytoplasmic.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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