PRMT2

RMT2 (Protein Arginine Methyltransferase 2) is a protein coding gene. Among its related pathways are mRNA Splicing-Major Pathway and Retinoblastoma (RB) in Cancer. Gene Ontology annotations related to this gene include protein homodimerization activity and transcription coactivator activity.

Full Name

Protein Arginine Methyltransferase 2

Function

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.

Biological Process

Developmental cell growthISS:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G1/S transition of mitotic cell cycleISS:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-arginine methylationIEA:InterPro
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein methylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Isoform 1
Cytoplasm
Nucleus
Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
Isoform PRMT2Alpha
Nucleus
Excluded from nucleolus.
Isoform PRMT2Beta
Cytoplasm
Nucleus
Nucleus, nucleolus
Isoform PRMT2Gamma
Nucleus
Excluded from nucleolus.
Isoform PRMT2L2
Cytoplasm
Nucleus
Predominantly cytoplasmic.