Human Recombinant PRMT2 protein, GST Tag (V2LY-0526-LY6316)

Name: Human Recombinant PRMT2 protein, GST Tag
SKU: V2LY-0526-LY6316
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PRMT2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 76 kDa.

Molecule Mass

76 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Protein Arginine Methyltransferase 2

Function

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.

Biological Process

Developmental cell growthISS:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of G1/S transition of mitotic cell cycleISS:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-arginine methylationIEA:InterPro
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein methylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Isoform 1
Cytoplasm
Nucleus
Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
Isoform PRMT2Alpha
Nucleus
Excluded from nucleolus.
Isoform PRMT2Beta
Cytoplasm
Nucleus
Nucleus, nucleolus
Isoform PRMT2Gamma
Nucleus
Excluded from nucleolus.
Isoform PRMT2L2
Cytoplasm
Nucleus
Predominantly cytoplasmic.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human PRMT2 ELISA Kit (CAT#: V2LY-0626-LY5084)

Related Products

Mouse Anti-PRMT2 Recombinant Antibody (3A3) (CAT#: CBMAB-P2934-YC)

Human PRMT2 ELISA Kit (CAT#: V2LY-0626-LY5084)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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