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Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578)


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Tested Data
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in WB
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in WB
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IHC
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IHC
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IHC
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IHC
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IF
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in IF
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in ELISA
Mouse Anti-PSIP1 Recombinant Antibody (CBT2756) (V2LY-0625-LY2578) in ELISA

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Rat
Clone
CBT2756
Antibody Isotype
IgG1
Application
WB, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human PSIP1 expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
11168
UniProt ID
O75475
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Biological Process
mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to heatISS:UniProtKB
Response to oxidative stressISS:UniProtKB
Cellular Location
Nucleus
Remains chromatin-associated throughout the cell cycle.
Involvement in disease
A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.
PTM
Citrullinated by PADI4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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