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Mouse Anti-PSIP1 Recombinant Antibody (CBYC-P687) (CBMAB-P3127-YC)

Provided herein is a Mouse monoclonal antibody against Human PC4 and SFRS1 interacting protein 1. The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF, IHC, IHC-P, WB.
See all PSIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Rat
Clone
CBYC-P687
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
The immunogen corresponding to human PSIP1 expressed in E. coli
Specificity
Human, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PC4 and SFRS1 interacting protein 1
Introduction
PSIP1 (PC4 And SFRS1 Interacting Protein 1) is a protein coding gene. Diseases associated with PSIP1 include Dermatitis, Atopic. Among its related pathways are ERK Signaling andAkt Signaling.
Entrez Gene ID
Human11168
Rat313323
Monkey664733
UniProt ID
HumanO75475
RatQ812D1
MonkeyF6W6Z6
Alternative Names
p75; DFS70; PSIP2; LEDGF; PAIP; p52
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Biological Process
mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to heatISS:UniProtKB
Response to oxidative stressISS:UniProtKB
Cellular Location
Nucleus
Remains chromatin-associated throughout the cell cycle.
Involvement in disease
A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.
PTM
Citrullinated by PADI4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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