PSIP1
PSIP1 (PC4 And SFRS1 Interacting Protein 1) is a protein coding gene. Diseases associated with PSIP1 include Dermatitis, Atopic. Among its related pathways are ERK Signaling andAkt Signaling.
Full Name
PC4 and SFRS1 interacting protein 1
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Biological Process
mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to heatISS:UniProtKB
Response to oxidative stressISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to heatISS:UniProtKB
Response to oxidative stressISS:UniProtKB
Cellular Location
Nucleus
Remains chromatin-associated throughout the cell cycle.
Remains chromatin-associated throughout the cell cycle.
Involvement in disease
A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.
PTM
Citrullinated by PADI4.
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Anti-PSIP1 antibodies
+ Filters
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Monkey
Clone: CBT843
Application*: WB, P, IF, IC, E
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: CBT2756
Application*: WB, IH, IC
Target: PSIP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: C57G11
Application*: WB, P, IF (IC), F
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C4
Application*: WB, E
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: CBYC-P687
Application*: E, IC, IF, IH, P, WB
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: 6E4
Application*: E, WB, P, IF, IC
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H1
Application*: E, P, WB
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: 13B651
Application*: E, IH, WB
Target: PSIP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJL-2326
Application*: WB, P, IF, F
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2325
Application*: WB, IC
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJL-2324
Application*: WB, E, IH, IC, IF
Target: PSIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2323
Application*: BI, WB, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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