PSIP1

PSIP1 (PC4 And SFRS1 Interacting Protein 1) is a protein coding gene. Diseases associated with PSIP1 include Dermatitis, Atopic. Among its related pathways are ERK Signaling andAkt Signaling.

PC4 and SFRS1 interacting protein 1

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to heatISS:UniProtKB
Response to oxidative stressISS:UniProtKB

Nucleus
Remains chromatin-associated throughout the cell cycle.

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.

Citrullinated by PADI4.