Mouse Anti-PTGDR2 Recombinant Antibody (8F2) (CBMAB-P3316-YC)

Name: Mouse Anti-PTGDR2 Recombinant Antibody (8F2)
SKU: CBMAB-P3316-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

8F2

Application

ELISA, WB

Immunogen

Partial peptide of Human GPR44

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Prostaglandin D2 Receptor 2

Introduction

PTGDR2 is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.

Entrez Gene ID

11251

UniProt ID

Q9Y5Y4

Alternative Names

GPR44; CRTH2; CD294; DL1R; DP2

Function

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of male germ cell proliferationIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl

Cellular Location

Cell membrane
Internalized receptors colocalized with RAB11A.

Topology

Extracellular: 1-33
Helical: 34-56
Cytoplasmic: 57-67
Helical: 68-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-146
Helical: 147-168
Extracellular: 169-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-269
Extracellular: 270-288
Helical: 289-308
Cytoplasmic: 309-395

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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