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Mouse Anti-PTGDR2 Recombinant Antibody (MM07098F56) (CBMAB-G6481-LY)

This product is antibody recognizes PTGDR2. The antibody MM07098F56 immunoassay techniques such as: FC.
See all PTGDR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MM07098F56
Antibody Isotype
IgG2
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Prostaglandin D2 Receptor 2
Introduction
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.
Entrez Gene ID
11251
UniProt ID
Q9Y5Y4
Alternative Names
CD294; CRTH2; DL1R; DP2; GPR44
Function
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of male germ cell proliferationIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular Location
Cell membrane
Internalized receptors colocalized with RAB11A.
Topology
Extracellular: 1-33
Helical: 34-56
Cytoplasmic: 57-67
Helical: 68-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-146
Helical: 147-168
Extracellular: 169-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-269
Extracellular: 270-288
Helical: 289-308
Cytoplasmic: 309-395
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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