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PTGDR2

PTGDR2 (Prostaglandin D2 Receptor 2) is a Protein Coding gene. Diseases associated with PTGDR2 include Folliculitis and Eosinophilic Pustular Folliculitis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Eicosanoid ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is C3AR1.
Full Name
Prostaglandin D2 Receptor 2
Function
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of male germ cell proliferationIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular Location
Cell membrane
Internalized receptors colocalized with RAB11A.
Topology
Extracellular: 1-33
Helical: 34-56
Cytoplasmic: 57-67
Helical: 68-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-146
Helical: 147-168
Extracellular: 169-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-269
Extracellular: 270-288
Helical: 289-308
Cytoplasmic: 309-395
PTM
Phosphorylated.
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Anti-PTGDR2 antibodies

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Human Anti-PTGDR2 Recombinant Antibody (CBXC-0890) (CBMAB-C2005-CQ)

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Target: PTGDR2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0890
Application*: F
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (301108) (CBMAB-C0927-LY)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 301108
Application*: F, MC
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (8F2) (CBMAB-P3316-YC)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8F2
Application*: E, WB
Datasheet SDS

Rat Anti-PTGDR2 Recombinant Antibody (BM16) (CBMAB-C3509-CQ)

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Target: PTGDR2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: BM16
Application*: F
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (CBXC-1081) (CBMAB-C1347-CQ)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1081
Application*: F
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (CBXC-1080) (CBMAB-C1346-CQ)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1080
Application*: F
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (CBXC-2592) (CBMAB-C0262-CQ)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2592
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (CBXC-2591) (CBMAB-C0261-CQ)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2591
Application*: WB
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (301109) (CBMAB-C0928-LY)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 301109
Application*: F, MC
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (MM07098F56) (CBMAB-G6481-LY)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM07098F56
Application*: F
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (54N3F8) (CBMAB-G6480-LY)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 54N3F8
Application*: P, WB
Datasheet SDS

Mouse Anti-PTGDR2 Recombinant Antibody (54N1H4) (CBMAB-G6479-LY)

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Target: PTGDR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 54N1H4
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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