PTGDR2

PTGDR2 (Prostaglandin D2 Receptor 2) is a Protein Coding gene. Diseases associated with PTGDR2 include Folliculitis and Eosinophilic Pustular Folliculitis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Eicosanoid ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is C3AR1.

Prostaglandin D2 Receptor 2

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of male germ cell proliferationIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl

Cell membrane
Internalized receptors colocalized with RAB11A.

Extracellular: 1-33
Helical: 34-56
Cytoplasmic: 57-67
Helical: 68-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-146
Helical: 147-168
Extracellular: 169-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-269
Extracellular: 270-288
Helical: 289-308
Cytoplasmic: 309-395

Phosphorylated.