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Mouse Anti-PTGDR2 Recombinant Antibody (301108) (CBMAB-C0927-LY)

This product is antibody recognizes PTGDR2. The antibody 301108 immunoassay techniques such as: FC, CyTOF.
See all PTGDR2 antibodies
Published Data
Fig.1 Expression of CRTH2 in Eol-1 cells.
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Fig.2 Expression of CRTH2 and different PKA and PKC in Eol-1 cells after VIP treatment.
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Fig.3 PGD2 and PGJ2 induce HA production in human orbital fibroblasts via DP1, but not DP2, activation.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
301108
Antibody Isotype
IgG2a
Application
FC, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human CRTH-2, Met1-Ser395, Accession # Q9Y5Y4
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Prostaglandin D2 Receptor 2
Entrez Gene ID
11251
UniProt ID
Q9Y5Y4
Function
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of male germ cell proliferationIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular Location
Cell membrane
Internalized receptors colocalized with RAB11A.
Topology
Extracellular: 1-33
Helical: 34-56
Cytoplasmic: 57-67
Helical: 68-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-146
Helical: 147-168
Extracellular: 169-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-269
Extracellular: 270-288
Helical: 289-308
Cytoplasmic: 309-395
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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