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Mouse Anti-PTGES Recombinant Antibody (2B9) (CBMAB-P3325-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin E synthase. The antibody can be used for immunoassay techniques, such as ELISA, IP.
See all PTGES antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Immunogen
PTGES (AAH08280.1, 1-152 aa) full length recombinant protein with GST tag. Immunogen sequence: MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR HL
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-152

Target

Full Name
prostaglandin E synthase
Introduction
PTGES is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis.
Entrez Gene ID
9536
UniProt ID
O14684
Alternative Names
2410099E23Rik; D2Ertd369e; Pges; mPGES; mPGES-1
Function
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105).
Plays a key role in inflammation response, fever and pain (By similarity).
Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824).
In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824).
Biological Process
Cell population proliferationIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of prostaglandin secretionIEA:Ensembl
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Prostaglandin metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of fever generationISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Sensory perception of painISS:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Membrane
Cytoplasm, perinuclear region
Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment.
Topology
Lumenal: 1-12
Helical: 13-41
Cytoplasmic: 42-60
Helical: 61-90
Lumenal: 91-95
Helical: 96-119
Cytoplasmic: 120-123
Helical: 124-152
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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