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Mouse Anti-PTGES3 Recombinant Antibody (CBYJT-1610) (CBMAB-T0654-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to PTGES3 (Prostaglandin E Synthase 3). The antibody can be used for immunoassay techniques, such as WB.
See all PTGES3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1610
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Recombinant corresponding to human Tsp23
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
prostaglandin E synthase 3 (cytosolic)
Introduction
PTGES3 is an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). PTGES3 plays a role as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes.
Entrez Gene ID
10728
UniProt ID
Q15185
Alternative Names
P23; TEBP; cPGES
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363).
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419).
Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Biological Process
Chaperone cofactor-dependent protein refoldingManual Assertion Based On ExperimentIDA:UniProtKB
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIMP:CAFA
Cyclooxygenase pathwayTAS:Reactome
Fibroblast proliferationIEA:Ensembl
Glucocorticoid receptor signaling pathwayIEA:Ensembl
Glycogen biosynthetic processIEA:Ensembl
Lung saccule developmentIEA:Ensembl
Positive regulation of phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Telomerase holoenzyme complex assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Telomere maintenanceManual Assertion Based On ExperimentTAS:UniProtKB
Telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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