PTGES3

PTGES3 is an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes.

Full Name

prostaglandin E synthase 3 (cytosolic)

Function

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363).
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419).
Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Biological Process

Chaperone cofactor-dependent protein refoldingManual Assertion Based On ExperimentIDA:UniProtKB
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIMP:CAFA
Cyclooxygenase pathwayTAS:Reactome
Fibroblast proliferationIEA:Ensembl
Glucocorticoid receptor signaling pathwayIEA:Ensembl
Glycogen biosynthetic processIEA:Ensembl
Lung saccule developmentIEA:Ensembl
Positive regulation of phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Telomerase holoenzyme complex assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Telomere maintenanceManual Assertion Based On ExperimentTAS:UniProtKB
Telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasm