PTGES3 is an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes.
Full Name
prostaglandin E synthase 3 (cytosolic)
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Biological Process
Chaperone cofactor-dependent protein refoldingManual Assertion Based On ExperimentIDA:UniProtKB Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIMP:CAFA Cyclooxygenase pathwayTAS:Reactome Fibroblast proliferationIEA:Ensembl Glucocorticoid receptor signaling pathwayIEA:Ensembl Glycogen biosynthetic processIEA:Ensembl Lung saccule developmentIEA:Ensembl Positive regulation of phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB Protein foldingManual Assertion Based On ExperimentIBA:GO_Central Protein stabilizationManual Assertion Based On ExperimentIMP:CAFA Signal transductionManual Assertion Based On ExperimentTAS:ProtInc Skin developmentIEA:Ensembl Telomerase holoenzyme complex assemblyManual Assertion Based On ExperimentIDA:BHF-UCL Telomere maintenanceManual Assertion Based On ExperimentTAS:UniProtKB Telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL