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Mouse Anti-PTGES3 Recombinant Antibody (JJ6) (CBMAB-P3331-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin E synthase 3. The antibody can be used for immunoassay techniques, such as ELISA, WB, IP.
See all PTGES3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rabbit, Chicken, Guinea pig
Clone
JJ6
Antibody Isotype
IgG1
Application
ELISA, WB, IP

Basic Information

Immunogen
Recombinant human full length p23 protein
Specificity
Human, Mouse, Rabbit, Chicken, Guinea pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
prostaglandin E synthase 3 (cytosolic)
Introduction
PTGES3 is an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes.
Entrez Gene ID
Human10728
Mouse56351
Guinea pig100718334
Chicken100859133
Rabbit100345490
Frog492275
UniProt ID
HumanQ15185
MouseQ9R0Q7
Guinea pigH0UT30
ChickenQ90955
RabbitG1TGF1
FrogQ5U4Z0
Alternative Names
cPGES; P23; TEBP
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363).
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419).
Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Biological Process
Chaperone cofactor-dependent protein refoldingManual Assertion Based On ExperimentIDA:UniProtKB
Chaperone-mediated protein complex assemblyManual Assertion Based On ExperimentIMP:CAFA
Cyclooxygenase pathwayTAS:Reactome
Fibroblast proliferationIEA:Ensembl
Glucocorticoid receptor signaling pathwayIEA:Ensembl
Glycogen biosynthetic processIEA:Ensembl
Lung saccule developmentIEA:Ensembl
Positive regulation of phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Telomerase holoenzyme complex assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Telomere maintenanceManual Assertion Based On ExperimentTAS:UniProtKB
Telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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