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Mouse Anti-PTGIS Recombinant Antibody (3B11) (CBMAB-P3336-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin I2 synthase. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTGIS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B11
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PTGIS (NP_000952, 391-500 aa) partial recombinant protein with GST tag. Immunogen sequence: PQRDPEIYTD PEVFKYNRFL NPDGSEKKDF YKDGKRLKNY NMPWGAGHNH CLGRSYAVNS IKQFVFLVLV HLDLELINAD VEIPEFDLSR YGFGLMQPEH DVPVRYRIRP
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 391-500

Target

Full Name
prostaglandin I2 (prostacyclin) synthase
Introduction
PTGIS is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation.
Entrez Gene ID
5740
UniProt ID
Q16647
Alternative Names
CYP8; CYP8A1; PGIS; PTGI
Function
Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769).
Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).
Biological Process
Apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to interleukin-6Manual Assertion Based On ExperimentIEP:UniProtKB
Cyclooxygenase pathwayTAS:Reactome
Icosanoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of execution phase of apoptosisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peroxisome proliferator activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Involvement in disease
Essential hypertension (EHT):
A condition in which blood pressure is consistently higher than normal with no identifiable cause.
Topology
Helical: 1-20
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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