Mouse Anti-PTGIS Recombinant Antibody (CBYC-P754) (CBMAB-P3337-YC)

Name: Mouse Anti-PTGIS Recombinant Antibody (CBYC-P754)
SKU: CBMAB-P3337-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYC-P754

Application

Immunogen

E. coli-derived Recombinant human Prostaglandin I2 Synthase, Arg21-Pro500

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

prostaglandin I2 (prostacyclin) synthase

Introduction

PTGIS is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation.

Entrez Gene ID

5740

UniProt ID

Q16647

Alternative Names

PTGI; PGIS; CYP8A1; CYP8

Function

Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769).
Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).

Biological Process

Apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to interleukin-6Manual Assertion Based On ExperimentIEP:UniProtKB
Cyclooxygenase pathwayTAS:Reactome
Icosanoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of execution phase of apoptosisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peroxisome proliferator activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Involvement in disease

Essential hypertension (EHT):
A condition in which blood pressure is consistently higher than normal with no identifiable cause.

Topology

Helical: 1-20

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PTGIS Recombinant Antibody (3B11) (CAT#: CBMAB-P3336-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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