PTGIS

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq]

Full Name

prostaglandin I2 (prostacyclin) synthase

Function

Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769).
Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).

Biological Process

Apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to interleukin-6Manual Assertion Based On ExperimentIEP:UniProtKB
Cyclooxygenase pathwayTAS:Reactome
Icosanoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of execution phase of apoptosisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peroxisome proliferator activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Involvement in disease

Essential hypertension (EHT):
A condition in which blood pressure is consistently higher than normal with no identifiable cause.

Topology

Helical: 1-20