Sign in or Register   Sign in or Register
  |  

Mouse Anti-PTPA Recombinant Antibody (13B638) (CBMAB-P2641-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 2 Phosphatase Activator. The antibody can be used for immunoassay techniques, such as ELISA, FC, IHC, WB.
See all PTPA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B638
Antibody Isotype
IgG1
Application
ELISA, FC, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 0.05% sodium azide and 0.5% protein stabilizer
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PTPA
Introduction
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families.
Entrez Gene ID
5524
UniProt ID
Q15257
Alternative Names
PP2A; PPP2R4; PR53
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity).
Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Biological Process
Mitotic spindle organizationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Cytoplasm
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PTPA Recombinant Antibody (13B638)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare