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Mouse Anti-PTPA Recombinant Antibody (5G3) (CBMAB-CP2059-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Monkey
Clone
5G3
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the mouse PPP2R4 protein.
Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PTPA
Entrez Gene ID
Human5524
Mouse110854
Rat362102
UniProt ID
HumanQ15257
MouseP58389
RatB2RYQ2
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity).
Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Biological Process
Mitotic spindle organizationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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