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PTPA

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family.
Full Name
PTPA
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity).
Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Biological Process
Mitotic spindle organizationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of protein dephosphorylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Cytoplasm
Nucleus
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Anti-PTPA antibodies

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Recombinant Mouse Anti-PTPA Recombinant Antibody (5A5-1F3) (CBMAB-XB0965-YC)

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Target: PTPA
Host: Mouse
Specificity: Human
Clone: 5A5-1F3
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-PTPA Antibody (10BA13) (CBMAB-1522CQ)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10BA13
Application*: E, WB
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (4G7) (CBMAB-CP3195-LY)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 4G7
Application*: WB
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (5G3) (CBMAB-CP2059-LY)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Monkey
Clone: 5G3
Application*: WB
Datasheet SDS

Mouse Anti-PTPA Monoclonal Antibody (2G9) (CBMAB-1746-YC)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 2G9
Application*: IP, WB
Datasheet SDS

Mouse Anti-PTPA Antibody (10BA15) (CBMAB-1524CQ)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10BA15
Application*: E, WB
Datasheet SDS

Mouse Anti-PTPA Antibody (10BA14) (CBMAB-1523CQ)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA14
Application*: E, M, WB
Datasheet SDS

Mouse Anti-PTPA Antibody (10BA12) (CBMAB-1521CQ)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10BA12
Application*: E, WB
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (CBT3750) (V2LY-0625-LY2720)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3750
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (CBYC-P576) (CBMAB-P2643-YC)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYC-P576
Application*: WB
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (4D9) (CBMAB-P2642-YC)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D9
Application*: WB, E, P, F, IC, IF
Datasheet SDS

Mouse Anti-PTPA Recombinant Antibody (13B638) (CBMAB-P2641-YC)

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Target: PTPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B638
Application*: E, F, IH, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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