Mouse Anti-HACD3 Recombinant Antibody (5B5) (CBMAB-A7219-LY)

Name: Mouse Anti-HACD3 Recombinant Antibody (5B5)
SKU: CBMAB-A7219-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5B5

Application

WB, ELISA

Immunogen

PTPLAD1 (NP_057479, 1 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

3-Hydroxyacyl-CoA Dehydratase 3

Entrez Gene ID

51495

UniProt ID

Q9P035

Alternative Names

B-IND1; FLJ90376; HSPC121

Function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

Biological Process

Fatty acid elongation Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: ProtInc
JNK cascade Source: Ensembl
Positive regulation by virus of viral protein levels in host cell Source: AgBase
Positive regulation of viral genome replication Source: AgBase
Rac protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: Ensembl
Small GTPase mediated signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: GO_Central
Very long-chain fatty acid biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-149
Helical: 150-170
Lumenal: 171-185
Helical: 186-207
Cytoplasmic: 208-217
Helical: 218-235
Lumenal: 236-241
Helical: 242-256
Cytoplasmic: 257-279
Helical: 280-298
Lumenal: 299-322
Helical: 323-343
Cytoplasmic: 344-362

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-HACD3 Recombinant Antibody (5B5) (CAT#: CBMAB-P0373-YC)

Related Products

Mouse Anti-HACD3 Recombinant Antibody (CBYC-P081) (CAT#: CBMAB-P0374-YC)

Mouse Anti-HACD3 Recombinant Antibody (5B5) (CAT#: CBMAB-P0373-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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