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Mouse Anti-PTPN5 Recombinant Antibody (CBYC-P781) (CBMAB-P3440-YC)

Provided herein is a Mouse monoclonal antibody against Rat Protein tyrosine phosphatase, non-receptor type 5. The antibody can be used for immunoassay techniques, such as IHC, IP, WB.
See all PTPN5 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYC-P781
Antibody Isotype
IgG
Application
IHC, IP, WB

Basic Information

Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PTPN5
Introduction
PTPN5 is a putative protein-tyrosine-phosphatase that is found enriched within the striatum.
Entrez Gene ID
29644
UniProt ID
P35234
Alternative Names
PTPSTEP; STEP; STEP61
Function
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
Biological Process
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
PTM
Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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