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PTPN5

PTPN5 is a putative protein-tyrosine-phosphatase that is found enriched within the striatum.
Full Name
PTPN5
Function
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
Biological Process
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
PTM
Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.
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Anti-PTPN5 antibodies

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Mouse Anti-PTPN5 Recombinant Antibody (2H5) (CBMAB-A7226-LY)

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Target: PTPN5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H5
Application*: IP, E
Datasheet SDS

Mouse Anti-PTPN5 Recombinant Antibody (T41) (CBMAB-S6655-CQ)

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Target: PTPN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: T41
Application*: WB
Datasheet SDS

Mouse Anti-PTPN5 Recombinant Antibody (CBXS-2230) (CBMAB-S4992-CQ)

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Target: PTPN5
Host: Mouse
Specificity: Human
Clone: CBXS-2230
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PTPN5 Recombinant Antibody (23E5) (CBMAB-S2832-CQ)

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Target: PTPN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 23E5
Application*: IP, WB
Datasheet SDS

Rabbit Anti-PTPN5 Recombinant Antibody (CBXS-5456) (CBMAB-S2666-CQ)

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Target: PTPN5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5456
Application*: WB, IP
Datasheet SDS

Rabbit Anti-PTPN5 Recombinant Antibody (CBXS-5431) (CBMAB-S2642-CQ)

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Target: PTPN5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-5431
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTPN5 Recombinant Antibody (CBYC-P781) (CBMAB-P3440-YC)

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Target: PTPN5
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P781
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-PTPN5 Recombinant Antibody (10E45) (CBMAB-P3439-YC)

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Target: PTPN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 10E45
Application*: IP, WB
Datasheet SDS

PTPN5 Matched Antibody Pair (945) (APMAB-945LY)

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Target: PTPN5
Specificity: Human
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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