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Mouse Anti-PTPN7 Recombinant Antibody (CBFYH-3640) (CBMAB-H4200-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Dog, Human
Clone
CBFYH-3640
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Specificity
Mouse, Rat, Dog, Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, non-receptor type 7
Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
Entrez Gene ID
Human5778
Mouse320139
Rat246781
Dog607227
UniProt ID
HumanP35236
MouseQ8BUM3
RatP49445
DogF1PUM2
Alternative Names
LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
Function
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Biological Process
MAPK cascadeTAS:Reactome
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
PTM
Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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