loading...

PTPN7

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.

Full Name

Protein tyrosine phosphatase, non-receptor type 7

Function

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.

Biological Process

MAPK cascadeTAS:Reactome
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton

PTM

Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine (By similarity).

View more

Anti-PTPN7 antibodies

+ Filters

Loading...

Mouse Anti-PTPN7 Recombinant Antibody (3B10) (CBMAB-P3448-YC)

Compare

Target: PTPN7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3B10

Application*: IF, WB

Human Recombinant Ptpn7, Active protein, GST Tag (V2LY-0526-LY6414)

Compare

Target: Ptpn7

Expressed Host: E. coli

Sequence: Amino Acid: Full Length

Tag: GST Tag

Mouse Anti-PTPN7 Recombinant Antibody (CBFYH-3640) (CBMAB-H4200-FY)

Compare

Target: PTPN7

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Rat, Dog, Human

Clone: CBFYH-3640

Application*: WB, IF

Mouse Anti-PTPN7 Recombinant Antibody (AFPK32) (CBMAB-H4199-FY)

Compare

Target: PTPN7

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: AFPK32

Application*: WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry