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Mouse Anti-PTPRJ Recombinant Antibody (6G11) (CBMAB-D2223-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6G11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to a.a.38-138, from human PTPRJ (NP_002834) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase, receptor type, J
Introduction
PTPRJ is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP.
Entrez Gene ID
5795
UniProt ID
Q12913
Alternative Names
DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA
Function
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Biological Process
B cell differentiationISS:ARUK-UCL
Calcium-mediated signaling using intracellular calcium sourceISS:ARUK-UCL
Contact inhibition1 PublicationNAS:UniProtKB
Cytokine-mediated signaling pathwayTAS:Reactome
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosisISS:ARUK-UCL
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPK cascadeISS:ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionISS:ARUK-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
T cell receptor signaling pathwayTAS:Reactome
Cellular Location
Cell membrane
Cell projection, ruffle membrane
Cell junction
After T-cell stimulation, it is temporarily excluded from immunological synapses.
Topology
Extracellular: 36-975
Helical: 976-996
Cytoplasmic: 997-1337
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

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