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Human Anti-PTPRJ Recombinant Antibody (CBXC-0742) (CBMAB-C1856-CQ)

This product is a recombinant human antibody that recognizes PTPRJ. The antibody CBXC-0742 can be used for immunoassay techniques such as: FC.
See all PTPRJ antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0742
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase, receptor type, J
Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
5795
UniProt ID
Q12913
Alternative Names
CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
Function
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Biological Process
B cell differentiationISS:ARUK-UCL
Calcium-mediated signaling using intracellular calcium sourceISS:ARUK-UCL
Contact inhibition1 PublicationNAS:UniProtKB
Cytokine-mediated signaling pathwayTAS:Reactome
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosisISS:ARUK-UCL
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPK cascadeISS:ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionISS:ARUK-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
T cell receptor signaling pathwayTAS:Reactome
Cellular Location
Cell membrane
Cell projection, ruffle membrane
Cell junction
After T-cell stimulation, it is temporarily excluded from immunological synapses.
Topology
Extracellular: 36-975
Helical: 976-996
Cytoplasmic: 997-1337
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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