PTPRJ

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

protein tyrosine phosphatase, receptor type, J

Function

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Biological Process

B cell differentiationISS:ARUK-UCL
Calcium-mediated signaling using intracellular calcium sourceISS:ARUK-UCL
Contact inhibition1 PublicationNAS:UniProtKB
Cytokine-mediated signaling pathwayTAS:Reactome
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosisISS:ARUK-UCL
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPK cascadeISS:ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionISS:ARUK-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
T cell receptor signaling pathwayTAS:Reactome

Cellular Location

Cell membrane
Cell projection, ruffle membrane
Cell junction
After T-cell stimulation, it is temporarily excluded from immunological synapses.

Topology

Extracellular: 36-975
Helical: 976-996
Cytoplasmic: 997-1337

PTM

N- and O-glycosylated.