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Mouse Anti-PTPRM Recombinant Antibody (C.337.3) (CBMAB-P3480-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type M. The antibody can be used for immunoassay techniques, such as IP, WB.
See all PTPRM antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mink, Mouse, Rat
Clone
C.337.3
Antibody Isotype
IgG2a
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to the amino-terminal residues of human PTPmu
Specificity
Human, Mink, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
10 mM HEPES with 150 mM sodium chloride, 100 μg/mL BSA, 50% glycerol, 0.02% sodium azide, pH 7.5
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type M
Introduction
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.
Entrez Gene ID
Human5797
Mouse19274
Rat29616
UniProt ID
HumanP28827
MouseP28828
RatF1LPJ1
Alternative Names
PTPRL1; R-PTP-MU; RPTPM; RPTPU; hR-PTPu
Function
Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:17761881, PubMed:10753936).
Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202).
Biological Process
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Retina layer formationManual Assertion Based On ExperimentIMP:UniProtKB
Retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Localizes in regions of cell-cell contact.
Topology
Extracellular: 21-742
Helical: 743-764
Cytoplasmic: 765-1452
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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