Mouse Anti-PTPRM Recombinant Antibody (C.337.3) (CBMAB-P3480-YC)

Name: Mouse Anti-PTPRM Recombinant Antibody (C.337.3)
SKU: CBMAB-P3480-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

C.337.3

Application

IP, WB

Immunogen

Synthetic peptide corresponding to the amino-terminal residues of human PTPmu

Specificity

Human, Mink, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

10 mM HEPES with 150 mM sodium chloride, 100 μg/mL BSA, 50% glycerol, 0.02% sodium azide, pH 7.5

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein tyrosine phosphatase, receptor type M

Introduction

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.

Entrez Gene ID

Human	5797
Mouse	19274
Rat	29616

UniProt ID

Human	P28827
Mouse	P28828
Rat	F1LPJ1

Alternative Names

PTPRL1; R-PTP-MU; RPTPM; RPTPU; hR-PTPu

Function

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:17761881, PubMed:10753936).
Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202).

Biological Process

Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Retina layer formationManual Assertion Based On ExperimentIMP:UniProtKB
Retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Localizes in regions of cell-cell contact.

Topology

Extracellular: 21-742
Helical: 743-764
Cytoplasmic: 765-1452

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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