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Mouse Anti-PTPRM Recombinant Antibody (CBT2744) (V2LY-0625-LY1071)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2744
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human PTPRM (AA: extra 565-742) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type M
Entrez Gene ID
5797
UniProt ID
P28827
Function
Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:17761881, PubMed:10753936).
Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202).
Biological Process
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Retina layer formationManual Assertion Based On ExperimentIMP:UniProtKB
Retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Localizes in regions of cell-cell contact.
Topology
Extracellular: 21-742
Helical: 743-764
Cytoplasmic: 765-1452
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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