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Mouse Anti-PTPRO Recombinant Antibody (3F4) (CBMAB-P3485-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type O. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTPRO antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PTPRO (AAH35960, 1-597 aa) full length recombinant protein with GST tag. Immunogen sequence: MGHLPTGIHG ARRLLPLLWL FVLFKNATAF HVTVQDDNNI VVSLEASDVI SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFKASYHG LYYIITLVVV NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF TRVNISYWEG KDFRTMLYKD FFKGKTVFNH WLPGMCYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT APYPPQNISV RIVNLNKNNW EEQSGNFPEE SFMRSQDTIG KEKLFHFTEE TPEIPSGNIS SGWPDFNSSD YETTSQPYWW DSASAAPESE DEFVSVLPME YENNSTLSET EKSTSGSFSF FPVQMILTWL PPKPPTAFDG FHIHIEREEN FTEYLMVDEE AHEFVAELKE PGKYKLSVTT FSSSGSCETR KSQSAKSLSF YISPSGEWIE ELTEKPQHVS VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPIIENLV PGAQYQVVIY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW TRPYLGVFRK YVVEMFYFNP ATMTSEWTTY YEIAATVSLT ASVVIFP
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-597

Target

Full Name
protein tyrosine phosphatase, receptor type, O
Introduction
PTPRO is a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis.
Entrez Gene ID
5800
UniProt ID
Q16827
Alternative Names
PTPROT; PTP-OC; GLEPP1; PTP-U2; NPHS6; PTPU2; R-PTP-O
Function
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
Biological Process
Axon guidanceISS:UniProtKB
Cell morphogenesisISS:UniProtKB
Glomerulus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyISS:UniProtKB
Monocyte chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of canonical Wnt signaling pathwayISS:UniProtKB
Negative regulation of cell-substrate adhesionISS:UniProtKB
Negative regulation of glomerular filtrationISS:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Negative regulation of retinal ganglion cell axon guidanceISS:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Podocyte differentiationISS:UniProtKB
Protein dephosphorylationISS:UniProtKB
Regulation of glomerular filtrationISS:UniProtKB
Regulation of synapse organizationIEA:Ensembl
Slit diaphragm assemblyISS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Nephrotic syndrome 6 (NPHS6):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
Topology
Extracellular: 30-822
Helical: 823-843
Cytoplasmic: 844-1216
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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