PTPRO

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression. [provided by RefSeq]

Full Name

protein tyrosine phosphatase, receptor type, O

Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).

Biological Process

Axon guidanceISS:UniProtKB
Cell morphogenesisISS:UniProtKB
Glomerulus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyISS:UniProtKB
Monocyte chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of canonical Wnt signaling pathwayISS:UniProtKB
Negative regulation of cell-substrate adhesionISS:UniProtKB
Negative regulation of glomerular filtrationISS:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Negative regulation of retinal ganglion cell axon guidanceISS:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Podocyte differentiationISS:UniProtKB
Protein dephosphorylationISS:UniProtKB
Regulation of glomerular filtrationISS:UniProtKB
Regulation of synapse organizationIEA:Ensembl
Slit diaphragm assemblyISS:UniProtKB

Cellular Location

Membrane

Involvement in disease

Nephrotic syndrome 6 (NPHS6):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.

Topology

Extracellular: 30-822
Helical: 823-843
Cytoplasmic: 844-1216