Human PTPRO ELISA Kit (V2LY-0626-LY3076)

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Tested Data
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0081 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
138.3 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
protein tyrosine phosphatase, receptor type, O
Function
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
Biological Process
Axon guidanceISS:UniProtKB
Cell morphogenesisISS:UniProtKB
Glomerulus developmentManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyISS:UniProtKB
Monocyte chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of canonical Wnt signaling pathwayISS:UniProtKB
Negative regulation of cell-substrate adhesionISS:UniProtKB
Negative regulation of glomerular filtrationISS:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Negative regulation of retinal ganglion cell axon guidanceISS:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Podocyte differentiationISS:UniProtKB
Protein dephosphorylationISS:UniProtKB
Regulation of glomerular filtrationISS:UniProtKB
Regulation of synapse organizationIEA:Ensembl
Slit diaphragm assemblyISS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Nephrotic syndrome 6 (NPHS6):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
Topology
Extracellular: 30-822
Helical: 823-843
Cytoplasmic: 844-1216
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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