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Mouse Anti-PTPRS Recombinant Antibody (1H6) (CBMAB-P3489-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type S. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTPRS antibodies
Published Data
Fig.1 Pharmacodynamic analysis of response of OE21 tumors.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H6
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PTPRS (AAH29496, 31-128 aa) full length recombinant protein with GST tag. Immunogen sequence: EPPRFIKEPK DQIGVSGGVA SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA KLTVLRGP
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 31-128

Target

Full Name
protein tyrosine phosphatase, receptor type, S
Introduction
PTPRS is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair.
Entrez Gene ID
5802
UniProt ID
Q13332
Alternative Names
PTPSIGMA
Function
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754).
Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829).
Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity).
Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity).
Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).
Biological Process
Negative regulation of axon extensionISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of collateral sproutingISS:UniProtKB
Negative regulation of dendritic spine developmentISS:UniProtKB
Negative regulation of interferon-alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Negative regulation of toll-like receptor 9 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Cellular Location
Cell membrane
Cell projection, axon
Perikaryon
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Postsynaptic density
Cell projection, neuron projection
Cell projection, growth cone
Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120).
Detected in a punctate pattern along neurites and axon growth cones (By similarity).
Topology
Extracellular: 30-1282
Helical: 1283-1303
Cytoplasmic: 1304-1948
PTM
A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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