Human Recombinant PTPRS, Active protein, GST Tag (V2LY-0526-LY6403)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829).
Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity).
Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity).
Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of collateral sproutingISS:UniProtKB
Negative regulation of dendritic spine developmentISS:UniProtKB
Negative regulation of interferon-alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of neuron projection developmentISS:UniProtKB
Negative regulation of toll-like receptor 9 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Cell projection, axon
Perikaryon
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Postsynaptic density
Cell projection, neuron projection
Cell projection, growth cone
Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120).
Detected in a punctate pattern along neurites and axon growth cones (By similarity).
Helical: 1283-1303
Cytoplasmic: 1304-1948
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant PTPRS protein, ECD, His Tag (CAT#: V2LY-0526-LY6402)
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Mouse Anti-PTPRS Recombinant Antibody (17G7.2) (CAT#: CBMAB-R0666-CN)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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