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Mouse Anti-PTS Recombinant Antibody (AT2B2) (CBMAB-1741-CN)

This product is a mouse antibody that recognizes PTS of human. The antibody AT2B2 can be used for immunoassay techniques such as: ELISA, WB.
See all PTS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AT2B2
Antibody Isotype
IgG2b, λ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein, corresponding to aa. 1-145 of Human PTS purified from E. coli (NP_000308).
Specificity
Human, Mouse
Antibody Isotype
IgG2b, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% Sodium Azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
6-pyruvoyltetrahydropterin synthase
Introduction
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Mutations in this gene result in hyperphenylalaninemia. Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. This protein catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Entrez Gene ID
Human5805
Mouse19286
UniProt ID
HumanQ03393
MouseQ9R1Z7
Alternative Names
PTPS
Function
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Biological Process
Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
cytoplasm
cytosol
mitochondrion
Involvement in disease
Hyperphenylalaninemia, BH4-deficient, A (HPABH4A):
An autosomal recessive disorder characterized by hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits. Neurological symptoms are unresponsive to the classic phenylalanine-low diet.
PTM
Phosphorylation of Ser-19 is required for maximal enzyme activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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