Mouse Anti-PTS Recombinant Antibody (D-8) (CBMAB-P3502-YC)

Name: Mouse Anti-PTS Recombinant Antibody (D-8)
SKU: CBMAB-P3502-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D-8

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

6-pyruvoyltetrahydropterin synthase

Introduction

PTS catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity.

Entrez Gene ID

5805

UniProt ID

Q03393

Alternative Names

PTPS

Function

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

Biological Process

Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytoplasm
cytosol
mitochondrion

Involvement in disease

Hyperphenylalaninemia, BH4-deficient, A (HPABH4A):
An autosomal recessive disorder characterized by hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits. Neurological symptoms are unresponsive to the classic phenylalanine-low diet.

PTM

Phosphorylation of Ser-19 is required for maximal enzyme activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PTS Recombinant Antibody (2B2) (CAT#: CBMAB-P3501-YC)

Mouse Anti-PTS Recombinant Antibody (AT2B2) (CAT#: CBMAB-1741-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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