Mouse Anti-RAB21 Recombinant Antibody (1F6) (CBMAB-R0741-CN)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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