RAB21
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM
Full Name
RAB21, member RAS oncogene family
Function
Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).
Biological Process
Biological Process anterograde axonal transportManual Assertion Based On ExperimentIDA:SynGO
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).
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Anti-RAB21 antibodies
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CompareTarget: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6H8
Application*: WB
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6G3
Application*: WB, IF, IH
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 6G1
Application*: WB, P
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: 6F6
Application*: WB
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 6F11
Application*: WB, P, IF
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog, Monkey
Clone: 6E12
Application*: WB, IH, IF
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6B1
Application*: WB, IH
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6A9
Application*: WB, IH, IF
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5B12
Application*: WB, IH
Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A6
Application*: WB, P, IF
Target: RAB21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F6
Application*: E, IF, IH, WB
Target: RAB21
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: 1701CT536.68.39
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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