RAB21

RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM
Full Name
RAB21, member RAS oncogene family
Function
Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).
Biological Process
Biological Process anterograde axonal transportManual Assertion Based On ExperimentIDA:SynGO
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).
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Anti-RAB21 antibodies

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Mouse Anti-RAB21 Recombinant Antibody (6H8) (CBMAB-R0752-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6H8
Application*: WB
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6G3) (CBMAB-R0751-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6G3
Application*: WB, IF, IH
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6G1) (CBMAB-R0750-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 6G1
Application*: WB, P
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6F6) (CBMAB-R0749-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: 6F6
Application*: WB
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6F11) (CBMAB-R0748-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 6F11
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6E12) (CBMAB-R0747-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog, Monkey
Clone: 6E12
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6B1) (CBMAB-R0746-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6B1
Application*: WB, IH
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (6A9) (CBMAB-R0745-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6A9
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (5B12) (CBMAB-R0744-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5B12
Application*: WB, IH
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (4A6) (CBMAB-R0743-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A6
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (1F6) (CBMAB-R0741-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F6
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-RAB21 Recombinant Antibody (1701CT536.68.39) (CBMAB-R0740-CN)

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Target: RAB21
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: 1701CT536.68.39
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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