RAB21

RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM

RAB21, member RAS oncogene family

Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).

Biological Process anterograde axonal transportManual Assertion Based On ExperimentIDA:SynGO
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB

Endoplasmic reticulum membrane
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).