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Mouse Anti-RAB21 Recombinant Antibody (5B12) (CBMAB-R0744-CN)

This product is a Mouse antibody that recognizes RAB21. The antibody 5B12 can be used for immunoassay techniques such as: WB, IHC.
See all RAB21 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B12
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human RAB21 (NP_055814) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
RAB21, member RAS oncogene family
Introduction
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
Entrez Gene ID
23011
UniProt ID
Q9UL25
Alternative Names
RAB21, Member RAS Oncogene Family; KIAA0118;
Function
Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435).
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity).
As a result, may regulate cell adhesion and migration (By similarity).
Involved in neurite growth (By similarity).
Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).
Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601).
Biological Process
Biological Process anterograde axonal transportManual Assertion Based On ExperimentIDA:SynGO
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendrite morphogenesisIEA:Ensembl
Biological Process positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of axon extensionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, trans-Golgi network
Golgi apparatus membrane
Early endosome membrane
Cytoplasmic vesicle membrane
Cleavage furrow
Cell projection, neuron projection
Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity).
In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961).
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435).
In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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