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Mouse Anti-RAB27B Recombinant Antibody (CBT3457) (V2LY-0625-LY1104)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3457
Antibody Isotype
IgG2a
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human RAB27B (AA: 2-218) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RAB27B, member RAS oncogene family
Entrez Gene ID
5874
UniProt ID
O00194
Function
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381).
Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604).
May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Biological Process
Biological Process anterograde axonal protein transportISS:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process multivesicular body sorting pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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