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Mouse Anti-RAB2A Recombinant Antibody (CB06A) (CBMAB-CA006LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog, Rat, Pig
Clone
CB06A
Antibody Isotype
IgG1
Application
ELISA, WB, ICC

Basic Information

Immunogen
Recombinant fragment, corresponding to amino acids 39-206aa of Human RAB2A (C-terminus).
Specificity
Human, Mouse, Dog, Rat, Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RAB2A, Member RAS Oncogene Family
Introduction
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human5862
Mouse59021
Rat65158
Dog404009
Pig100151822
UniProt ID
HumanP61019
MouseP53994
RatP05712
DogP61105
PigF1RT87
Alternative Names
RAB2A, Member RAS Oncogene Family; RAB2, Member RAS Oncogene Family; RAB2; Small GTP Binding Protein RAB2A; Ras-Related Protein Rab-2A; LHX;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
Biological Process
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Melanosome
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cytoplasmic vesicle, secretory vesicle, acrosome
Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
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For research use only. Not intended for any clinical use.

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