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Mouse Anti-RAB3IP Recombinant Antibody (5D1) (CBMAB-R0870-CN)

This product is a Mouse antibody that recognizes RAB3IP. The antibody 5D1 can be used for immunoassay techniques such as: WB.
See all RAB3IP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5D1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human RAB3IP (NP_071901) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
RAB3A Interacting Protein
Introduction
RAB3IP (RAB3A Interacting Protein) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAB3IL1.
Entrez Gene ID
UniProt ID
Alternative Names
RAB3A Interacting Protein; Rab3A-Interacting Protein; Rabin-3; Rabin3; RABIN8; Rab-3A-Interacting Protein; SSX2 Interacting Protein; SSX2-Interacting Protein;
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392).
Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392).
Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392).
Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131).
Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).
Biological Process
Biological Process ciliary basal body-plasma membrane dockingTAS:Reactome
Biological Process cilium assemblyIMP:BHF-UCL
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi to plasma membrane transportTAS:BHF-UCL
Biological Process negative regulation of filopodium assemblyIEA:Ensembl
Biological Process protein localization to organelleIMP:BHF-UCL
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Vesicle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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