RAB3IP

RAB3IP (RAB3A Interacting Protein) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAB3IL1.
Full Name
RAB3A Interacting Protein
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392).
Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392).
Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392).
Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131).
Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).
Biological Process
Biological Process ciliary basal body-plasma membrane dockingTAS:Reactome
Biological Process cilium assemblyIMP:BHF-UCL
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi to plasma membrane transportTAS:BHF-UCL
Biological Process negative regulation of filopodium assemblyIEA:Ensembl
Biological Process protein localization to organelleIMP:BHF-UCL
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Vesicle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia.
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Anti-RAB3IP antibodies

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Mouse Anti-RAB3IP Recombinant Antibody (5H1) (CBMAB-R0874-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H1
Application*: WB
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (5G4) (CBMAB-R0873-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G4
Application*: WB
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (5F2) (CBMAB-R0872-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: 5F2
Application*: WB, IH
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (5D3) (CBMAB-R0871-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D3
Application*: WB
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (5D1) (CBMAB-R0870-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D1
Application*: WB
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (4B1) (CBMAB-R0869-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B1
Application*: WB
Datasheet SDS

Mouse Anti-RAB3IP Recombinant Antibody (4A7) (CBMAB-R0868-CN)

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Target: RAB3IP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A7
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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