Mouse Anti-RAB3IP Recombinant Antibody (5F2) (CBMAB-R0872-CN)
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Basic Information
Target
Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392).
Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392).
Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131).
Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).
Biological Process cilium assemblyIMP:BHF-UCL
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi to plasma membrane transportTAS:BHF-UCL
Biological Process negative regulation of filopodium assemblyIEA:Ensembl
Biological Process protein localization to organelleIMP:BHF-UCL
Biological Process protein targeting to membraneManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Vesicle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Mouse Anti-RAB3IP Recombinant Antibody (4B1) (CAT#: CBMAB-R0869-CN)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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