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Mouse Anti-RAB6B Recombinant Antibody (6D12E4) (CBMAB-R0928-CN)

This product is a Mouse antibody that recognizes RAB6B. The antibody 6D12E4 can be used for immunoassay techniques such as: ELISA, WB, IHC-P, IF, FC.
See all RAB6B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
6D12E4
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF, FC

Basic Information

Immunogen
Recombinant fragment of human Rab6b (aa. 95-208) expressed in E. Coli
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.05% Sodium azide

Target

Full Name
RAB6B, Member RAS Oncogene Family
Introduction
RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB6A.
Entrez Gene ID
Human51560
Rat363123
UniProt ID
HumanQ9NRW1
RatF1LVC3
Alternative Names
RAB6B, Member RAS Oncogene Family;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Regulates the compacted morphology of the Golgi (PubMed:26209634).
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369).
Biological Process
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection developmentManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process protein localization to Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Golgi apparatus membrane
Endoplasmic reticulum-Golgi intermediate compartment
Cytoplasmic vesicle
Colocalizes with BICD1 at vesicular structures that align along microtubules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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