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Mouse Anti-Rab6b Recombinant Antibody (CBT4486) (V2LY-0625-LY485)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBT4486
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human Rab6b (AA: 95-208) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RAB6B, Member RAS Oncogene Family
Entrez Gene ID
51560
UniProt ID
Q9NRW1
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Regulates the compacted morphology of the Golgi (PubMed:26209634).
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369).
Biological Process
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection developmentManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process protein localization to Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Golgi apparatus membrane
Endoplasmic reticulum-Golgi intermediate compartment
Cytoplasmic vesicle
Colocalizes with BICD1 at vesicular structures that align along microtubules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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