RAB6B

RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB6A.

Full Name

RAB6B, Member RAS Oncogene Family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Regulates the compacted morphology of the Golgi (PubMed:26209634).
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369).

Biological Process

Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection developmentManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process protein localization to Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retrograde transport, endosome to GolgiManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Golgi apparatus membrane
Endoplasmic reticulum-Golgi intermediate compartment
Cytoplasmic vesicle
Colocalizes with BICD1 at vesicular structures that align along microtubules.