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Mouse Anti-RAD1 Recombinant Antibody (CBCNR-106) (CBMAB-R1035-CN)

This product is a Mouse antibody that recognizes RAD1. The antibody CBCNR-106 can be used for immunoassay techniques such as: WB, IHC-P.
See all RAD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-106
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
No preservatives

Target

Full Name
RAD1 homolog (S. pombe)
Introduction
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
Entrez Gene ID
5810
UniProt ID
O60671
Alternative Names
RAD1 Checkpoint DNA Exonuclease; Rad1-Like DNA Damage Checkpoint Protein; Cell Cycle Checkpoint Protein Hrad1; DNA Repair Exonuclease Rad1 Homolog; Checkpoint Control Protein HRAD1; RAD1 Checkpoint Clamp Component; DNA Repair Exonuclease REC1; Exonuclease Homolog RAD1; HRAD1;
Function
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395).
The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958).
Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698).
The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698).
The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603).
Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to ionizing radiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process DNA damage checkpoint signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process meiotic recombination checkpoint signalingManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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