Mouse Anti-RAD1 Recombinant Antibody (CBCNR-107) (CBMAB-R1036-CN)

Name: Mouse Anti-RAD1 Recombinant Antibody (CBCNR-107)
SKU: CBMAB-R1036-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-107

Application

WB, ELISA, IHC-P

Specificity

Human

Antibody Isotype

IgG3

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

RAD1 homolog (S. pombe)

Introduction

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Entrez Gene ID

5810

UniProt ID

O60671

Alternative Names

RAD1 Checkpoint DNA Exonuclease; Rad1-Like DNA Damage Checkpoint Protein; Cell Cycle Checkpoint Protein Hrad1; DNA Repair Exonuclease Rad1 Homolog; Checkpoint Control Protein HRAD1; RAD1 Checkpoint Clamp Component; DNA Repair Exonuclease REC1; Exonuclease Homolog RAD1; HRAD1;

Function

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395).
The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958).
Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698).
The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698).
The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603).
Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to ionizing radiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process DNA damage checkpoint signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process meiotic recombination checkpoint signalingManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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